Testing drugs and vaccines against viral hemorrhagic fever viruses
Christina Spiropoulou, PhDCenters for Disease Control and Prevention, Atlanta, Georgia, United States of America
Viral hemorrhagic fever viruses (VHFs) include a very diverse collection of viruses including Ebola, Marburg, Lassa, Nipah and Crimean-Congo hemorrhagic fever among others. In humans, the VHF viruses often affect mainly the vascular endothelium, resulting in edema, shock and multiorgan failure in severe cases. Common VHF features are high virus diversity and low disease incidence, creating considerable challenges to the study of these viruses from the characterization of animal models to the development of vaccines or therapeutics. This presentation will highlight our progress in three areas: 1) the generation of tools to allow the visual tracking of VHF virus infections in small animal models; 2) the manipulation of the VHF virus genomes in order to identify effective antivirals or therapeutics and determination of their mechanism of action, and 3) the engineering of safe and efficacious prototype VHF vaccines.
The International Society for Antiviral Research (ISAR) is an internationally recognized organization for scientists involved in basic, applied, and clinical aspects of antiviral research. The Society main event is the annual International Conference on Antiviral Research (ICAR), a truly interdisciplinary meeting which attracts the interest of chemists, biologists, and clinicians.