ISAR Webinar Series
The International Society for Antiviral Research invites you to join us for a webinar at 10 AM EDT on Wednesday, Sept 18, 2019
Speaker: Prof. Dr. Volker Lohmann, Department of Infectious Diseases, University of Heidelberg, Heidelberg, Germany
Topic: Hepatitis C virus replication in cell culture: past, present and future.
Chronic Hepatitis C virus (HCV) infections affect 71 million people worldwide, often resulting in severe liver damage. Since 2014 highly efficient therapies based on direct acting antivirals (DAAs) are available, offering cure rates of almost 100%, if the infection is diagnosed in time. It took more than a decade to discover HCV in 1989 and another decade to establish the first cell culture model, which was essential for therapy development, from drug screening to understanding of mode of action and resistance. More recently we are beginning to understand the molecular basis for efficient HCV replication in cell culture, which is highly dependent on the shaping of the lipid composition of the membranous viral replication organelle, mediated by host factors like PI4KA and SEC14L2. This presentation will provide a short introduction into the history of HCV cell culturing, summarize our current knowledge on the mechanism of action of host factors involved in this process and provide an outlook on future opportunities based on our increasing understanding of molecular mechanisms of HCV replication.
We will be using GoToWebinar, which is compatible with a Mac, PC or mobile device. To register, go to
Previous Webinars can be accessed by ISAR Members on this page
The International Society for Antiviral Research (ISAR) is an internationally recognized organization for scientists involved in basic, applied, and clinical aspects of antiviral research. The Society main event is the annual International Conference on Antiviral Research (ICAR), a truly interdisciplinary meeting which attracts the interest of chemists, biologists, and clinicians.