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International Society for Antiviral Research


ICAR2020 Abstracts

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Broadly neutralizing antibodies targeting HIV-1

Florian Klein, MD

Institute of Virology, University of Cologne, Germany


Broadly neutralizing antibodies (bNAbs) targeting HIV-1 can prevent infection in animal models and are under investigation for passive immunization in clinical trials. Moreover, bNAbs have been demonstrated to suppress viremia in HIV-1-infected individuals. While these results highlight the significant clinical potential of bNAbs, pre-existing and de novo HIV-1 resistance causes treatment failure and limits bNAb applications in humans. Strategies to overcome viral escape and to enhance the efficacy of bNAbs are therefore critical.


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