Institute of Virology, University of Cologne, Germany
Broadly neutralizing antibodies (bNAbs) targeting HIV-1 can prevent infection in animal models and are under investigation for passive immunization in clinical trials. Moreover, bNAbs have been demonstrated to suppress viremia in HIV-1-infected individuals. While these results highlight the significant clinical potential of bNAbs, pre-existing and de novo HIV-1 resistance causes treatment failure and limits bNAb applications in humans. Strategies to overcome viral escape and to enhance the efficacy of bNAbs are therefore critical.
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